Moreover, it is rearranged with the deletion del(13)(q13q14) in B-cell chronic lymphocytic leukaemia (CLL), the translocations t(12;13)(p13;q12) and t(12;15)(13p;q25) are common in acute myeloid leukaemia (AML), translocation t(12;13)(p13;q14) in acute lymphoblastic leukaemia (ALL) and deletion del(13)(q13q14) in retinoblastoma (RB1). This evidence concerns the gene RB1 and acute lymphoblastic leukemia.