On chromosome 13, the most frequent cancer-associated chromosomal aberration close to reuse breakpoints identified from multispecies genome comparisons are the ones involving: gene ZNF198 (ZMYM2) translocation t(8;13) (p11;q12), which is linked to chronic myeloproliferative disorder and stem cell leukaemia lymphoma syndrome (SCLL); and gene FOXO1 translocation t(2;13)(q36;q14), linked to alveolar rhabdomyosarcoma. The gene discussed is FOXO1; the disease is rhabdomyosarcoma.