CXCL8 and neoplasm: Most pronounced among the neutrophil-recruiting/-activating chemokines produced by tumor cells and structural cells in the TME are CXCL5 (also known as epithelial neutrophil-activating peptide-78; ENA-78) and CXCL8 (interleukin-8; IL-8) [14,15,16,17,18,19,20,21,22,23,24].