TGFB1 and neoplasm: Based on the findings of Fridlender et al. [59], that TGFβ1 promotes the reprogramming of anti-tumor TANs of the N1 phenotype to N2 pro-tumorigenic TANs in the TME, targeting of this immunosuppressive cytokine using mAbs, drugs or other agents represents a potential strategy to counter the emergence of MDSCs.