The top 20 enriched pathways for positive and negative correlations to CHA2DS2-VASc score are presented in the Table 3 and Table 4, respectively, and both results showed similar enriched pathways such as epithelial-mesenchymal transition, sex hormone signaling, TGF-β signaling, and epigenetic alterations, etc. As representative pathways, pathway map for “Development_Regulation of epithelial-to-mesenchymal transition (EMT)” and “Androgen receptor activation and downstream signaling in Prostate cancer” provided in the Metabase knowledgebase are presented in Figure 4. This evidence concerns the gene AR and Familial prostate cancer.