The top 20 enriched pathways for positive and negative correlations to CHA2DS2-VASc score are presented in the Table 3 and Table 4, respectively, and both results showed similar enriched pathways such as epithelial-mesenchymal transition, sex hormone signaling, TGF-β signaling, and epigenetic alterations, etc. As representative pathways, pathway map for “Development_Regulation of epithelial-to-mesenchymal transition (EMT)” and “Androgen receptor activation and downstream signaling in Prostate cancer” provided in the Metabase knowledgebase are presented in Figure 4. The gene discussed is TGFB1; the disease is prostate carcinoma.