Moreover, tumor cells themselves express molecules such as CLEC-2 and integrins (e.g. RGD-binding integrins like αvβ3, αvβ5, αvβ6, αvβ8, α5β1 and α8β1) that foster platelet activation and, therefore, generate a prothrombotic milieu. The gene discussed is CLEC1B; the disease is neoplasm.