PDPN and neoplasm: On the tumor-cell side, this includes extravasation-promoting molecules such as CCL2, angiopoietin like 4 (ANGPTL4) or podoplanin, whereas immune cells such as platelets produce TGF-β, CXCL5/7 and ATP and, thereby, target tumor cells, granulocytes/neutrophils and endothelial cells, respectively, which also induces extravasation of the tumor cells [83].