Although cats also suffer from long-term adverse effects of elevated LH concentrations following spaying/neutering (e.g., polyphagia, aggression and anxiety, diabetes), at the current time, the benefits of gonad removal (e.g., elimination of urine marking, recurrent/persistent estrus, mammary adenocarcinoma) outweigh these detriments. This evidence concerns the gene PLOD1 and diabetes mellitus.