The hypoxic phenotype is predominantly driven by hypoxia-inducible factors (HIFs), which induce the transcription of many genes with tumour-promoting functions, including genes related to angiogenesis (e.g., VEGF, PIGF, EPO), pH homeostasis (e.g., CAIX), glycolysis (e.g., GLUT1, PDK1), migration, the extracellular matrix and iron transport [7,8,9,10]. This evidence concerns the gene VEGFA and neoplasm.