In conclusion, the novel study showed that RES and AJM could act as multi-target directed ligands and can be used to develop into novel compound that can be used against several targets Aβ42, AChE, BuChE, MAO-B, BACE-1, and ROS that are implicated in AD and thus, help in alleviation of symptoms and having disease modifying effect in AD. This evidence concerns the gene BACE1 and Alzheimer disease.