LTF and nonpapillary renal cell carcinoma: Among these candidates, the transcriptional profile of the hallmark gene set, which reflects the activity of cellular EMT from the Molecular Signatures Database (MSigDB), appeared to be highly activated upon LTF downregulation in metastatic ccRCC, as demonstrated by the highest enrichment score, but predominantly inhibited in nonmetastatic ccRCC with high LTF expression, as demonstrated by the lowest enrichment score in the GSEA simulation (Figure 4C).