In our NCKU-OrCA-40TN cohort, we noticed that five collagen subunits are upregulated genes in the tumor tissues compared to that in the normal counterparts, including COL1A1 (3.5×), COL4A1 (2.1×), COL4A2 (3.3×), COL4A5 (5.6×), and COL4A6 (9.2×). This evidence concerns the gene COL4A5 and neoplasm.