Regarding pathological protein aggregates, micromolar zinc has been reported to induce aggregation of other proteins, including Aβ and Tau in the context of neurodegenerative diseases [31,52,53], factor H in relation to age-related macular degeneration [54], and tubulin, inducing atypical polymerization [55]. The gene discussed is MAPT; the disease is neurodegenerative disease.