In this regard, Barbero and colleagues demonstrated that Wnt5a signaling forced melanoma cells to produce and secrete IL-6, IL-11, IL-8, IL6 soluble receptor, TNF soluble receptor I and MCP-1, that were, in turn, responsible for angiogenesis, cell proliferation, exhaustion of effector T cells, pharmacological resistance, and cancer cell survival. The gene discussed is IL6; the disease is melanoma.