A cellular thermal shift assay verified the intracellular interaction between Anxa2 and (20S)G-Rh2 (Figure 3A): an immuno-precipitation as well as NF-κB luciferase reporter assay confirmed the inhibitory impact on NF-κB by (20S)G-Rh2 (Figure 3B,C and Figure 4A) in breast cancer cell line MDA-MB-231 and MCF-7. Here, ANXA2 is linked to breast cancer.