Over-expression of Anxa2 in invasive breast cancer MDA-MB-231 cells accelerated NF-κB activation (Figure 2A) and the expression EMT-TFs including SLUG, SIP1 and TWIST1 (Figure 2B,C), followed by the down-regulation of E-cadherin and up-regulation of N-cadherin (Figure 2B,C). The gene discussed is CDH2; the disease is invasive breast carcinoma.