Direct docking of SAMHD1 to DCAF1 is essential for Vpx-mediated SAMHD1 degradation during human immunodeficiency virus 2 (HIV-2) and simian immunodeficiency virus (SIV) infections via the CRL4-DCAF1 ubiquitin ligase complex [110,111]. The gene discussed is SAMHD1; the disease is infection.