Interestingly, studies found that latent HCMV infection of CD34+ progenitor cells downregulated expression of various HIV-1 restriction factors, including SAMHD1, APOBEC3G, and Mx2, while upregulating the expression of HIV-1 coreceptors CXCR4 and CCR5 [185]. Here, SAMHD1 is linked to cytomegalovirus infection.