CRHR2 and Anxiety: While expression of both ligands and receptor follows cycling of estrogen levels, androgens appear to dampen stress responses and reduce anxiety-like behaviors in male rodents by increasing expression of CRF2 [103,105], which is consistent with our observations, vis-à-vis, a role for CRF2 in exerting protective effects in inflammation and metabolic stress in peripheral tissues [7,34,92,93].