The increase in the survival and amelioration of colitis symptoms in Crhr2 heterozygous male mice is attributed to UCN1′s ability to decrease levels of TNF-α, interleukin (IL)-6, and IL-1β as well as restore mitogen-activated protein kinase (MAPK) and heat shock protein 27 signaling in a sex-specific manner [92]. Here, UCN is linked to colitis.