We found that Calebin A inhibited TNF-β-induced phosphorylation and translocation of p65 from the cytoplasm to the cell nucleus and suppressed NF-κB-regulated tumor-promoting biomarkers that are involved in invasion (MMP-9), metastasis (CXCR4, β1-integrin), proliferation (Ki-67) and upregulated apoptosis (caspase-3). The gene discussed is CASP3; the disease is neoplasm.