Calebin A suppressed and synergized with 5-FU in TNF-β-promoted CRC cell proliferation by downregulation of CXCR4, β1-integrin and Ki-67, which are responsible for proliferation and tumor invasion, highlighting the tremendous multitargeting potential role of Calebin A in the prevention of cancer cell proliferation, invasion, metastasis and apoptosis (Figure 8). This evidence concerns the gene CXCR4 and cancer.