Further, TNF-β, produced by tumor-associated lymphocytes in the tumor environment, has been shown to promote angiogenesis by signaling through the canonical NF-κB pathway [47], and in Hodgkin lymphoma, autocrine signaling of TNF-β has been described to drive disease progression by sustaining NF-κB activation [46]. Here, NFKB1 is linked to Hodgkins lymphoma.