Furthermore, we found significantly more apoptotic cells in CRC treated with Calebin A by itself or treated with Calebin A and with TNF-β or 5-FU or TNF-β and 5-FU in HCT116 (42%, 36%, 45% and 40%, respectively) or HCT116R cells (39%, 40%, 35% and 38%, respectively). The gene discussed is LTA; the disease is colorectal carcinoma.