Further clues of the anti-fibrotic potential of KL in the lung include Kl-heterozygous hypomorphic allele mice displayed exacerbated asbestos- [16] and bleomycin- [13] induced pulmonary fibrosis, and that both recombinant KL (rKL) supplementation and Kl-overexpression attenuated pulmonary fibrosis response. This evidence concerns the gene KL and pulmonary fibrosis.