However, longitudinal cohort studies have shown that most ZIKV-infected individuals sero-revert to IgM-negative by 3–4 months[30,31] and 70% do so by 6 months.[32] Given that human gestation is approximately 40 weeks, a ZIKV IgM-positive result indicates a substantially elevated risk for ZIKV infection during the current pregnancy, particularly when the tested specimen is obtained beyond 20 weeks of gestation. The gene discussed is CD40LG; the disease is Zika virus infectious disease.