CD4 cell count testing is important to aid in identifying ambulatory and asymptomatic patients eligible for further AHD screening and a result of CD4 cell count less than 200cells/mm3 triggers screening for urinary mycobacterial tuberculosis lipoarabinomannan antigen (TB LAM) and cryptococcal antigen (CrAg) [2] using TB LAM and CrAg POC lateral flow assays (LFA). Here, CD4 is linked to mitochondrial DNA depletion syndrome 4a.