We suggest that a higher level of demyelination and axonal loss in MS cases expressing meningeal lymphoid‐like structures may in part be related to the increased immune cell infiltration in the cord meninges, which via the production of pro‐inflammatory cytokines and chemokines, including TNF, IL6, IFNγ and CXCL13, could cause direct and/or indirect damage to the underlying tissues (18, 28, 37, 38). This evidence concerns the gene IL6 and myeloid sarcoma.