On the one hand, KIT is needed for cell development and survival (Blume-Jensen et al., 2000; Hou et al., 2000; Wen et al., 2010), but on the other hand, excessive KIT signaling, associated, for instance, with activating KIT mutations, may also lead to formation of tumors, in particular gastrointestinal stromal tumors, adult acute myeloid leukemia, and melanoma (Lennartsson and Rönnstrand, 2012). Here, KIT is linked to gastrointestinal stromal tumor.