It is known that limited light stress activates the FGF2/gp130 signaling pathway (Liu et al., 1998; Ueki et al., 2009) and that prolonged exposure to light upregulates CNTF and FGF2, although usually at levels too low to protect against retinal degeneration (LaVail et al., 1998; Wen et al., 1998). Here, FGF2 is linked to retinal degeneration.