In addition, other adipocyte-derived secretory proteins, such as collagen VI and its cleavage derivative endotrophin, plasminogen activator inhibitor-1 (PAI-1), and insulin-like growth factor binding protein 2 (IGF-BP2), were also shown to enhance the proliferative, migratory, and invasive capabilities of breast cancer cells (Iyengar et al., 2005; Carter and Church, 2012; Park and Scherer, 2012; Wang et al., 2015). The gene discussed is IGFBP2; the disease is breast cancer.