Intriguingly, it was found that adipocytes co-cultured with breast cancer cells would undergo apparent phenotypic changes, such as decreased lipid content, gain of fibroblast-like cell morphology, decreased expression levels of late adipocyte differentiation markers like peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT enhancer-binding protein alpha (C/EBPα), and enhanced expression levels of pro-inflammatory cytokines including interleukin-6 (IL-6), IL-1β, and others (Dirat et al., 2011; Wang et al., 2012). This evidence concerns the gene IL1B and breast cancer.