In consideration of the fact that, in clinical breast cancer tissue samples, enhanced G-CSF expression in adipocytes is well correlated with high p-Stat3 level in cancer cells, these results provide not only novel mechanisms for the bidirectional influences between breast cancer and adipocytes/CAAs, but also new evidence for targeting CAAs or G-CSF/Stat3 signaling in treating disseminating TNBC. This evidence concerns the gene STAT3 and breast carcinoma.