ROC curve analysis shows that the three DUX4 target gene scores are weak, but significant discriminators of FSHD status, statistically equivalent to the FSHD Lymphoblast score, but all are inferior classifiers of FSHD muscle biopsies to PAX7 target gene repression (32,33) using DeLong’s test (Supplementary Material, Figure S4). This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.