NR3C1 and acute lymphoblastic leukemia: While most glucocorticoid sensitisers are also glucocorticoid specific, Obatoclax has been shown to resensitise drug-resistant primary ALL cells to daunorubicin, vincristine and cytarabine, as well as dexamethasone.43 GCS-3 requires a functional GR to sensitise cells to glucocorticoids, but when combined with dexamethasone did not increase GR expression.