The ALL-4CL is derived from the ALL-4 xenograft and maintains resistance to glucocorticoids while expressing a functional GR.18 As seen with the ALL-4 xenograft, the GCS-3/dexamethasone combination was synergistic in ALL-4CL (Fig. 3c, Supplementary Table S6). This evidence concerns the gene NR3C1 and acute lymphoblastic leukemia.