Thirteen B-ALL xenografts including five dexamethasone-sensitive xenografts (ALL-54, ALL-17, ALL-55, ALL-56 and ALL-3) and eight dexamethasone-resistant xenografts (ALL-19, ALL-2, ALL-50, ALL-7, ALL-88, ALL-84, ALL-4 and MLL-5) were tested. This evidence concerns the gene KMT2E and acute lymphoblastic leukemia.