Clustering analysis of the frequency of events targeting CDK4, CCND1, CDKN2A, and RB1 indicates analyzed human cancers fall into five distinct groups separated largely by RB1 status and the co-occurrence of CCND1, CDK4, and CDKN2A (Fig. 1g and Supplementary Fig. 8). The gene discussed is CDKN2A; the disease is cancer.