In multiple other tumor types (BRCA-breast, OV-ovarian, LIHC-liver hepatocellular carcinoma, LUAD-lung adenocarcinoma) there is a diversity of single copy deletions that ultimately coalesce over the genetic region around the RB1 locus, but not BRCA2 which is located on the same chromosome arm (Fig. 2a, b and Supplementary Fig. 9). The gene discussed is RB1; the disease is lung adenocarcinoma.