Concerning the correlation between TAS2R38 and sinonasal diseases, in 2013, a pilot study on 28 patients with chronic rhinosinusitis demonstrated that supertaster patients (i.e., those with the highest activity of the TAS2R38 receptor being homozygous for the PAV allele) had a reduced risk of progressing to a disease requiring surgery. The gene discussed is TAS2R38; the disease is chronic rhinosinusitis.