The cell lines investigated were: T47D (breast cancer, luminal A), SKBr-3 (breast cancer, HER2-positive), HCT116 (colon cancer), BxPC-3 (pancreatic cancer), MCF10A (non-tumorigenic mammary epithelial cells), and NIH3T3 (mouse fibroblasts). This evidence concerns the gene ERBB2 and familial pancreatic carcinoma.