In fact, ASK1 levels were elevated in subcutaneous (inguinal) adipose tissue of HFD compared to chow-fed mice, and HFD-fed mice with adipocyte-specific ASK1 depletion depicted increased browning of inguinal WAT as well as increased energy expenditure, reduced body weight, blunted liver steatosis and improved glucose metabolism. The gene discussed is MAP3K5; the disease is Hepatic steatosis.