In fact, ASK1 levels were elevated in subcutaneous (inguinal) adipose tissue of HFD compared to chow-fed mice, and HFD-fed mice with adipocyte-specific ASK1 depletion depicted increased browning of inguinal WAT as well as increased energy expenditure, reduced body weight, blunted liver steatosis and improved glucose metabolism. Here, MAP3K5 is linked to fatty liver disease.