Similarly, Lu et al.20 interrogated WES data from Ambry Genetics for 2051 women with ovarian carcinoma for only a small number of known ‘cancer-associated’ genes, and demonstrated significant enrichment for variants in six genes (ATM, CHEK2, MSH6, PALB2, RAD51C and TP53). This evidence concerns the gene RAD51C and ovarian carcinoma.