The results of qRT-PCR and western blot showed that the mRNA and protein levels of cyclin D1 and Bcl-2 were significantly decreased while that of Bax were increased in sh-UFC1 transfected NSCLC cells (Fig. 2f, g), indicating that UFC1 is involved in the regulation of cell apoptosis and cell cycle progression in NSCLC cells. Here, BAX is linked to non-small cell lung carcinoma.