As shown in Fig. 3a, b, L-TAMS began to significantly attenuate the decrease in the mechanical withdrawal threshold in the cystitis model from day 12 after the first CYP injection (F(2, 21) = 108.2, P < 0.05 vs. CYP group for “a”; F(3, 52) = 107.6, P < 0.01 vs. CYP group for “b”). The gene discussed is PPIG; the disease is cystitis.