In all cases, 11C-(R)-PK11195 was used as a translocator protein (TSPO) binding to mitochondrial peripheral benzodiazepine sites upregulated in microglia and other mononuclear phagocytes in response to proinflammatory stimuli or in neurodegenerative conditions such as Alzheimer’s disease [31]. Here, TSPO is linked to early-onset autosomal dominant Alzheimer disease.