VEGFA and neoplasm: Therefore, assessment of specific tumor characteristics and biomarkers [e.g., tumor site (right versus left colon), mismatch repair capability, KRAS, NRAS, and BRAF proto-oncogenes mutational statuses] is now deemed mandatory for treatment selection in patients with mCRC, and the main therapeutic options in this setting include chemotherapy drugs, targeted therapies against the EGFR (Epidermal Growth Factor Receptor), and VEGF (Vascular Endothelial Growth Factor) pathways and immunotherapy [6].