Chronologically, the role of 2′-O-methylation in regulating the translation of selected mRNAs was first demonstrated through the observation of associations between altered 2′-O-methylation profiles and translation vector reporter assays in breast cancer models [21, 62] and subsequently in models in which expression of FBL was knocked down [21, 22, 50, 63]. The gene discussed is FBL; the disease is breast carcinoma.