XIAP and neoplasm: They identified three out of 1500 mRNAs whose expression was specifically decreased in polysome-associated fractions for DKC1m lymphocytes: the p27 tumor suppressor, the anti-apoptotic proteins XIAP (X-linked Inhibitor of Apoptosis Protein), both of which harbor IRES elements, and Bcl-xL showed a significant decrease in their association with polysomes in DKC1m cells compared with wild-type cells [75].