In human mammary epithelial cells, the diminution or suppression of p53 expression leads to modifications in the rRNA methylation pattern at the single nucleotide level, impairment of translational fidelity, and increased IRES-dependent translation of key cancer-related genes, such as IGF-1R, C-MYC, VEGF-A, and FGF1/2 [21]. This evidence concerns the gene TP53 and cancer.