Transcriptional regulators that exhibited higher activities in the basal-like tumors compared to the other breast cancer subtypes include BRF1, CTCFL, E2F1, FOXM1, GTF2B, GTF3C2, HCFC1, KAT2A, MEF2C, MYBL2, MYC, POLR3G and WRNIP1. The gene discussed is BRF1; the disease is breast cancer.