Eleven transcription regulators (ATF3, BATF, ESR1, FOXA1, GTF2B, IKZF1, IRF1, JUNB, KDM1A, MAX and STAT2) had a hazard ratio less than 1, suggesting that higher activity of these transcription regulators in breast tumors might be beneficial for patient survival. The gene discussed is ESR1; the disease is breast neoplasm.