Transcriptional regulators that exhibited higher activities in the basal-like tumors compared to the other breast cancer subtypes include BRF1, CTCFL, E2F1, FOXM1, GTF2B, GTF3C2, HCFC1, KAT2A, MEF2C, MYBL2, MYC, POLR3G and WRNIP1. Here, HCFC1 is linked to breast cancer.