In addition, while the expression levels of various SEMA3 family members were positively correlated with each other averaged across cancer types based on Spearman Correlation tests, we found that the pairs SEMA3A and SEMA3C (r = 0.40, P < .0001), SEMA3C and SEMA3F (r = 0.46, P < .0001) had the highest correlation among all the pairwise correlations of the 7 genes, suggesting they may share some common features or functions (Fig. 1c). This evidence concerns the gene SEMA3C and cancer.