Although our findings are similar to previous studies about SEMA3B and SEMA3D with both pro- and anti-tumoural activities, and SEMA3G mainly playing anti-tumoural roles, we observed that SEMA3E mainly associated with poor prognosis as opposed to previous reports that it can have a dual role and suppress tumour progression under certain circumstances [3, 7, 9, 12, 13, 24, 26]. The gene discussed is SEMA3E; the disease is neoplasm.