SEMA3A and neoplasm: More interestingly, our results show that SEMA3A, SEMA3C, and SEMA3F are more closely clustered and associated with more aggressive immune subtypes and tumour stem-cell-like features, indicating a role in immune response and drug resistance, which may explain the results that both SEMA3C and SEMA3F are likely involved in cancer cell resistance to a number of chemotherapy drugs.