Correlations between higher levels of SEMA3A, SEMA3C, and SEMA3F and type 1, 2, and 6 infiltrates (C1, C2 and C6), indicated a tumour promoter role of these gene members, as patients belonging to those categories had worse survival characterized with higher proliferation rate and enriched with TGFβ (Fig. 3 and Additional file 4: Figure S4A). This evidence concerns the gene SEMA3C and neoplasm.