As mentioned above, we found that SEMA3B, SEMA3D, SEMA3E, and SEMA3G were all negatively associated with cancer-stem like features, but SEMA3A, SEMA3C, and SEMA3F were positively correlated with DNAss, which indicates that SEMA3s may associate with cancer cell sensitivity or resistance to chemotherapy treatment. This evidence concerns the gene SEMA3A and cancer.