Interestingly, all the genes with decreased expression in breast cancer tumour showed significantly higher expression in normal like-tumours than in other more aggressive subtypes, i.e., Her2, LumA, LumB, and Basal type, except for SEMA3E, which also shows higher expression in Her2 type tumours, one of the most aggressive type of breast cancer subtypes. The gene discussed is TMEM43; the disease is breast cancer.