SEMA3A, SEMA3D, and SEMA3E showed relatively lower level of expression averaged across all cancer types compared to the rest of the SEMA3 family members, .i.e., SEMA3B, SEMA3C, SEMA3F and SEMA3G, where SEMA3F had the highest expression (Fig. 1a). The gene discussed is SEMA3F; the disease is cancer.