For example, expression levels of SEMA3E showed the largest inter-tumour heterogeneity with some tumours having very low levels of SEMA3E (ACC, DLBC, HNSC, KIRC, KIRP, AML, and PCPG), while others were characterized with high levels of SEMA3E expression (BRCA, CCA, and GBM) (Fig. 1a and Additional file 4: Figure S2). Here, SEMA3E is linked to acute myeloid leukemia.