Interestingly, our study found that all SEMA3 family members significantly associated with immune infiltrate subtypes in tumour microenvironment, where SEMA3A, SEMA3C, SEMA3E, and SEMA3F correlated with more aggressive subtypes of immune infiltrates, i.e., C1, C2, and C6, indicating a correlation with poor prognosis. This evidence concerns the gene SEMA3E and neoplasm.