HES1 and myeloid sarcoma: As MS remyelinating therapies become more sought after, this suggests that genes involved in the enriched function for regulation of glial cells may be of interest: CTNNB1, HDAC1, HES1 and RELA. Interestingly, epidermal growth factor receptor (EGFR) was shown as central within our top 1 % IMSGC gene modules (Additional file 4: Figure S3), and involvement of growth factors signaling pathways, phosphotyrosine residue binding and protein phosphorylated amino acid binding are supported by our gene set enrichment analysis.