The genes found to be involved in MS virus receptor activity may be of interest for experimental validation of this viral onset hypothesis: CD80, CD86, ITGB3 and TNFRSF14. Finally, the genes involved in T-cell costimulation may also be further investigated to discover if the autoimmune response in MS truly occurs through this immune response activation pathway: CD80, CD86, CSK, CTLA4, GRB2, MAP3K14 and TNFRSF14. The gene discussed is CTLA4; the disease is myeloid sarcoma.