As MS remyelinating therapies become more sought after, this suggests that genes involved in the enriched function for regulation of glial cells may be of interest: CTNNB1, HDAC1, HES1 and RELA. Interestingly, epidermal growth factor receptor (EGFR) was shown as central within our top 1 % IMSGC gene modules (Additional file 4: Figure S3), and involvement of growth factors signaling pathways, phosphotyrosine residue binding and protein phosphorylated amino acid binding are supported by our gene set enrichment analysis. This evidence concerns the gene RELA and myeloid sarcoma.