Chronic viral infections such as Cytomegalovirus, Herpes Simplex Virus and HCV are common in adult populations and can result in altered T-cell immune responses, which may be related to various chronic diseases, frailty, and longevity.[62] Measurement of IP-10 and other type I and II IFN-induced chemokines in large population-based samples of older adults, and comparison of predictive models with other inflammatory markers, may shed further light on the role of T-cell immune response and immune dysfunction in healthy and less healthy aging. Here, CXCL10 is linked to immune system disorder.