Thus, we systemically reviewed relevant references and conducted a meta-analysis to summarize the predictive ability of serum/urine NGAL and serum cystatin C and to further compare those indicators on different occasions in order to provide significant evidence for the early diagnosis of CIN, which may provide more benefits for timely intervention and improvement of prognosis. The gene discussed is CST3; the disease is cervical squamous intraepithelial neoplasia.