Meanwhile, the lower mean Ki67 in D21 despite increased number and lumen area of blood vessels is due to the presence of abnormal/dysmorphic vasculature common in gliomas and replicated in the Gl261 model [31–33]; expanded vessels, increased leakage, and loss of branching complexity [33] leading to reduced Ki67 proliferation and regions of geographic necrosis. The gene discussed is MKI67; the disease is glioma.