In particular, AMPK can improve mitochondrial autophagy originated from reactive oxygen damage [64], for instance, AMPK has been identified as a sensor of oxidative stress to elicit neuronal atrophy in Huntington’s disease [15] and regulate neurodegenerative diseases via mitochondrial autophagy in Alzheimer’s disease [62]. Here, PRKAA2 is linked to early-onset autosomal dominant Alzheimer disease.