Mechanistically, lncRNAs are proved by former studies to interact with RBPs to regulate gene expression.24 hnRNP U, recognized as a regulator of mRNA transporting and processing,19, 20, 21 was previously reported to perform suppressive roles in cancers by regulating DNA damage response and cell apoptosis.22, 23 Interestingly, a study has shown that lncRNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity by stabilizing GADD45A through hnRNP U in lung squamous cell carcinoma.24 Accordingly, our study confirmed that hnRNP U was downregulated in NSCLC cells. This evidence concerns the gene HNRNPU and cancer.