In the validation set, HAND2‐AS1 and CTD‐2033D15.2 were in negative correlation with the four stepwise stages of IPMN (P in one‐way ANOVA test = 2.66E‐03 and 1.47E‐04), and lncRNA‐TFG in positive correlation with the progression (P = 6.23E‐08). The gene discussed is HAND2; the disease is pancreatic intraductal papillary-mucinous neoplasm.