Thirdly, this could also be a sign of a) survival bias, as most patients with SDB may have transitioned to AD and only those with very low cortical atrophy or high in cognitive reserve at disease onset would remain as HC or MCI at cross‐section; or b) selection bias due to matching by the APOE4 allele, as it has been reported that the APOE4 allele interacts with brain aging scores measured by the BrainAGE method, revealing potential neuronal compensation in healthy APOE4+ adults (Scheller et al., 2018), which could also result in null findings. The gene discussed is APOE; the disease is Alzheimer disease.