INS and cancer: To determine direct effects of KDE on catabolism when controlling for confounding variables of cancer and anorexia, KDE was evaluated in an inflammation‐induced atrophy environment of LPS‐induced sepsis, which has been shown to produce an overlapping multifactorial atrophy environment of low IGF‐1/insulin, systemic inflammation, anorexia, anemia, hypoalbuminemia, metabolic derangement, and upregulated ubiquitin proteasome signaling.2 Due to the rapid nature of LPS‐induced atrophy, various dosages of KDE were gavaged to determine their ability to rapidly shift systemic metabolism.