Additionally, our work demonstrates that oral administration of R/S 1,3‐Butanediol Acetoacetate Diester, a novel synthetic ketone diester (KDE), supplemented in addition to a standard diet, was well‐tolerated, diminished anorexia, induced alterations in systemic metabolism, attenuated tumor burden indices, and reduced skeletal muscle atrophy despite circulating anabolic hormones, IGF‐1 and insulin, remaining significantly reduced. This evidence concerns the gene INS and neoplasm.