INS and Anorexia: Additionally, our work demonstrates that oral administration of R/S 1,3‐Butanediol Acetoacetate Diester, a novel synthetic ketone diester (KDE), supplemented in addition to a standard diet, was well‐tolerated, diminished anorexia, induced alterations in systemic metabolism, attenuated tumor burden indices, and reduced skeletal muscle atrophy despite circulating anabolic hormones, IGF‐1 and insulin, remaining significantly reduced.