Through analyzing the pathological features in ESCC specimens, we showed that SNHG12 expression was related to tumor size (P = 0.001), TNM stage (P = 0.016), and lymph node metastasis (P = 0.003) in ESCC patients (Table 1), indicating that SNHG12 potentially participated in tumorigenesis and metastasis in ESCC. The gene discussed is SNHG12; the disease is neoplasm.