We also observed that administration of A151 dampened the expression of AIM2 inflammasome‐related molecules (AIM2/caspase‐1/ASC) at early time point of 24 h after MCAO and that A151 reduced levels of IL‐1β, and several downstream inflammatory cytokines/chemokines (IL‐6, MCP‐1) at early time points of 6 and 24 h (Appendix Fig S1), suggesting the anti‐inflammatory effect of A151 treatment initiated after the onset of cerebral ischemia. Here, AIM2 is linked to brain ischemia.