Among them are some of the most important discoveries from the first cancer genomics era, for instance, B2M, STAG2, IDH1, IDH2, ARID1A, SPOP, KDM6A, RHOA, CASP8, or PIK3R1, as well as genes that were initially linked to cancer only via translocations and are now known to be altered by somatic single nucleotide variants, such as EP300. The gene discussed is CASP8; the disease is cancer.