Out of the 299 cancer driver genes recently described in the Pan‐Cancer Atlas analysis of TCGA, only TP53 has a median somatic mutation frequency over 10% across all cancer types (35%) and only ten other genes have a median frequency above 1% (ARID1A, ATM, BRAF, KMT2C, KRAS, NF1, PIK3CA, PTEN, RB1, and SMARCA4). The gene discussed is TP53; the disease is cancer.