HSP90AA1 and neoplasm: In contrast to Hsp90β, expression of Hsp90α can even be induced by short-term stress (Sreedhar et al. 2004), and its high expression was shown to be associated with various tumor progression (Gress et al. 1994; Yufu et al. 1992), enhanced cell cycle regulation (Jerome et al. 1993), and growth factor-mediated signal transduction via tyrosine kinases (Jerome et al. 1991).