Extracellular Hsp90 is also involved in wound healing (Li et al. 2012) and it is considered to be a key player in malignant invasion (angiogenesis, tumor cell motility and migration, cancer metastasis) (Sidera and Patsavoudi 2009; Tsutsumi and Neckers 2007). The gene discussed is HSP90AA1; the disease is cancer.