The model that was most strongly associated with recurrence-free survival (R2 = 0.341, AIC = 500.918, p < 0.001) included tumor size (defined as diameter ≤ 2 cm, 2–4 cm or > 4 cm), the intensity of the color reaction for p53 determined by the IS (range 0–3), and the intensity of the nuclear reaction for Ki-67 (category 1: IS = 0–2, or 2: IS = 3), and survivin (category 1: IS = 0–1, or 2: IS = 2–3). The gene discussed is BIRC5; the disease is neoplasm.