GPT and malaria: There were 5 severe AEs recorded in 3 subjects that were all considered to be related to malaria: headache, elevated alanine aminotransferase (ALT; 519 U/L [13 times the upper limit of normal]), elevated aspartate aminotransferase (AST; 319 U/L [8 times the upper limit of normal]), and lymphopenia (n = 2, 0.41 × 109/L and 0.32 × 109/L).